Microbiome Sequencing Services Market Dynamics and Key Players

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The microbiome sequencing services market is projected to grow from USD 284 million in 2023 to USD 555 million by 2028 at a CAGR of 14.3%. Growth in this market is majorly driven by the increasing demand for metagenomic sequencing, the growing focus on human microbiome therapeutics development, and the high cost of advanced infrastructure for sequencing. However, a dearth of skilled personnel is expected to hinder the growth of this market during the forecast period.

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The global microbiome sequencing services market is a fragmented market, with Charles River Laboratories (US), Eurofins Scientific (France), and BGI (China) emerging as the top leading players of the global market. Other prominent players/service providers include CosmosID (US), Microba (Australia), QIAGEN (Germany), Microbiome Insights (Canada), BaseClear (Netherlands), CD Genomics (US), Zymo Research (US), OraSure Technologies (US), MR DNA (US), Eremid Genomic Services (US), Clinical-Microbiomics A/S (Denmark), Novogene Co., Ltd. (China), EzBiome (US), Boster Biological Technology (US), Zifo (India), omics2view.consulting GbR (Germany), and Macrogen, Inc. (South Korea).

CRL is the leading player in the microbiome sequencing services market. CRL offers customized and flexible sequencing solutions, supported by its comprehensive portfolio of drug discovery and research models and services. The company has focused on both organic and inorganic growth through expansions and partnerships. For instance, CRL partnered with Fios Genomics Ltd. (UK) to gain access to its bioinformatics solutions, helping CRL to develop a full spectrum of microbiome profiling/analysis services. In addition, the strong reach of CRL’s microbial detection product, Accugenix, is contributing to the company’s dominant position in the market.

OPPORTUNITY: Expanding applications of microbiome sequencing in therapeutics development

Oral microbiome sequencing can provide insights into the microbial etiology of oral health conditions, identify key pathogenic species or functional genes associated with oral diseases, and reveal potential therapeutic targets for intervention. This knowledge can be used to develop novel strategies for oral health management, including probiotics, antimicrobial treatments, and personalized oral care regimens tailored to an individual's oral microbiome.

CHALLENGE: Issues related to sample preparation/isolation of microbes for sequencing

Despite the success of using metagenomic sequence data to guide the isolation and cultivation of microbes, there are still challenges and limitations that need to be addressed for more widespread success. Anaerobic microbes may also pose technical challenges for some targeted isolation methods due to limitations with cell sorters. Determining suitable growth media and physicochemical conditions for target organisms based solely on genome sequences can be challenging, as natural environment compositions are often unknown. Contamination can also be a significant challenge in microbiome research, as it can introduce non-target microbial DNA from external sources during sample collection, processing, and sequencing. Contamination can arise from reagents, equipment, and environmental sources, leading to false-positive or false-negative results. Proper controls, including negative controls and rigorous contamination prevention measures, should be implemented to minimize contamination and ensure accurate and reliable sequencing results.

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North America is the largest regional market for microbiome sequencing services. US has emerged as the key revenue contributor to this region. The US market is a rapidly growing and dynamic market that is driven by several factors. One of the key drivers for market growth in the US is the increasing awareness and understanding of the role of the microbiome in human health. Research has shown that microorganisms residing in and on the human body play a crucial role in various physiological processes, including digestion, immunity, and metabolism.

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